Source Tones
If you play electric guitar, knowing how to use your pickup selector is key to nailing the right guitar tone. In conjunction with the strings and technique, the pickup is a SOURCE of your sound.
In general, a bridge pickup position is brighter with a more forward midrange. A neck pickup position has more bass and less aggressive high end.
Which one you select is dependent on taste and artistic expression. Having awareness of your tone is essential to delivering a convincing performance.
Through experience and acute awareness, you can manipulate your sound by flipping to the neck pickup to fatten up the signal; or flip to the bridge to bring some bite to the strum.